Various approaches have been used to retain the dosage form in the stomach as a way of increasing the gastric residence time, including floatation systems; high-density systems; mucoadhesive systems; magnetic systems; unfoldable, extendible or swellable systems and superporous hydrogel systems. Trimebutine maleate has a short elimination half-life and is mainly absorbed in proximal areas of GIT. The purpose of this study was to develop a gastroretentive controlled release drug delivery system for the drug. Tablet formulations were designed using Hydroxypropylmethylcellulose (HPMC K15M) or Hydroxypropylmethylcellulose (HPMC K100M) as release-retarding polymers and sodium bicarbonate (NaHCO3) and citric acid as a gas former. Floating behavior and drug release studies were conducted in 0.1 N HCl (pH 1.2) at 37±0.5˚C. The tablets showed acceptable physicochemical properties. Drug release profiles of all formulae followed non-Fickian diffusion. Statistical analyses of data revealed that tablets containing HPMC K100 (1:0.75), citric acid (4%, w/w) and NaHCO3 (3.5%, w/w) were promising systems exhibiting were promising systems exhibiting excellent floating properties and sustained drug release characteristics. The formulae were stored at 40 ˚C/75% RH for 3 months according to ICH guidelines. Formula F23 showed better physical stability.
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